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Overview
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Galectin-3 is a 30-kD protein, a member of the beta-galactosidase-binding lectin family. Galectin-3 isassociated with cell growth, adhesion, inflammation, mRNA processing, and apoptosis. Reportedly, Galectin-3 aberrant expression is related to malignant transformation and metastasis in carcinomas ofthe breast, colon and thyroid. Galectin-3 reactivity can be seen in the nucleus of neutrophils, vascularendothelium, carcinomas of the colon, breast, and thyroid. Galectin-3 may be useful in thedifferentiation of benign and malignant thyroid neoplasms. Galectin-3 may also be useful in theidentification of certain liver disorders.
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Overview