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Overview
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Reacts with galectin-3, a 30 kDa protein. Galectin-3 is a member of the galectin family. Theprotein is composed of three domains: a small amino-terminal domain, a carboxyl-terminalcarbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements.Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, includingmacrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulatedduring inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.The expression is also affected by neoplastic transformation: up-regulated in certain types oflymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such ascolon, breast, ovarian and uterine carcinomas. The epitope of is found within the first 45amino acids of galectin-3, does not react with Galecin-3C and is cross reactive with mouse galectin-3.Immunogen: Recombinant human Galectin-3
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