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Overview
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Reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels onmemory T-cells tend to increase. CD11a plays a key role in mediating leukocyte adhesion toendothelium during inflammatory response through binding to ICAM 1 (CD54). Other ligands areICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. Whenpaired with CD18, it forms the integrin alphaL beta2 adhesion.
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- Properties
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Overview