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Overview
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Reacts with human CD26 (Dipeptidyl peptidase IV), a 110 kDa protein which occurs in thecell membrane of T-lymphocyte and is upregulated after activation. CD26 is also present onendothelial cells and also expressed on activated B-cells and natural killer cells and abundantlyon epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, celladhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Crosslinking ofCD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production.In Western blotting, this mAb reacts with only glycosylated CD26, but not with deglycosylatedforms.
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