Name: Anti-CD16 antibody
Price: 855.00 USD

- Overview
  - CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms-a transmembranousform expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed bygranulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediatingADCC by NK cells. Human CD16 is expressed in two forms ì FCGR3A and FCGR3B. FCGR3A isassociated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cellcytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A canbe triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed onneutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseasesassociated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.Immunogen: Human CD16
    
    Please contact us at for specific academic pricing.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Reactivity
    
    human
    
    Clone
    
    3G8
    
    Immunogen
    
    Human CD16
    
    Conjugate
    
    PE
    
    Formulation
    
    0.5 ml purified antibody, conjugated to R-PE, in Phosphate Buffer Saline solution containing sucrose, 4 mg/ml BSA and 0.1% sodium azide.
    
    Storage
    
    Store antibody at 2-8°C until expiry. Avoid prolonged exposure to light.
    
    Concentration
    
    approximately 0.2 mg/ml
    
    Regulatory Status
    
    RUO
    
    * For research use only
- Applications
  - Application
    
    Flow Cytometry