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Overview
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CD16 is a protein encoded by the FCGR3A gene which is approximately 29 kDa. CD16 is localised to the cell membrane. It is involved in the immune response role of DAP12 receptors in NK cells, regulation of actin dynamics for phagocytic cup formation and the role of phospholipids in phagocytosis. It is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from circulation, as well as other antibody-dependent responses. CD16 is expressed on natural killer cells, macrophages, a subpopulation of T-cells, immature thymocytes and placental trophoblasts. Mutations in the FCGR3A gene may result in an immunodeficiency. STJ96992 was developed from clone Q32 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous CD16 protein.
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