Clavulanic Acid Potassium w/ Cellulose (1:1)

- Overview
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    Background
    
    Clavulanate is a potent suicide inhibitor of β -lactamases. It forms a covalent bond with a serine residue in the enzyme’s active site. Inhibition is time-dependent and irreversible. Clavulanic acid β-lactam antibiotics bind and inhibit PBPs (penicillin binding protein) thus inhibiting bacterial cell wall synthesis.
- Properties
  - CAS Number
    
    61177-45-5
    
    Molecular Formula
    
    Mixture
    
    Molecular Weight
    
    Mixture
    
    Appearance
    
    White or almost white powder
    
    Other Properties
    
    Source: Mixture
    Water Content (Karl Fischer): ≤2.5%
    PH: 4.8-8.0
    Assay: 48.0-53.5% (on dried basis) (Clavulanic acid potassium)
    Absorbance: ≤0.4 at 278nm
    Purity Level: 1:1
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: Clavulanic acid had poor activity against S.aureus, Enterobacteriaceae, and P. aeruginosa. However, it can act synergistically with penicillins and cephalosporins to inhibit β -lactamase-producing S. aureus and Enterobacteriaceae.