Sulfathiazole Sodium

- Overview
  - Sulfathiazole Sodium is a bacteriostatic sulfonamide antibiotic. Sulfathiazole acts as a competitor with para-aminobenzoic acid (PABA) in the folic acid synthesis pathway. It is used in veterinary research in animal models to inhibit folate formation by gut bacteria. Sulfathiazole Sodium is sparingly soluble in aqueous solution.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Sulfonamide will be catalyzed to competitive combine with the pteridine instead of the para-aminobenzoic acid (PABA) during folic acid synthesis, inhibiting production of folic acid. Resistance is due to the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
- Properties
  - CAS Number
    
    144-74-1
    
    Molecular Formula
    
    C9H8N3NaO2S2
    
    Molecular Weight
    
    277.30
    
    Appearance
    
    White or yellowish crystalline powder
    
    Other Properties
    
    Source: synthetic
    PH: (1% in water) 9.0 - 10.0
    Assay: (On dried basis): 99.0% - 101.0%
    Heavy Metals: Not more than 20 ppm
    Loss on Drying: 6.0 - 10.0%
    
    Storage
    
    <30°C, protected from light
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Sulfathiazole is a broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria and mycoplasma.
    
    Microbiology Applications: Sulfathiazole Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.
    Representative MIC values include:
    Haemophilus parasuis 32 µg/mL - 512 µg/mL