Sulfapyridine Sodium

Sulfapyridine Sodium is the sodium salt of Sulfapyridine, a first generation sulfonamide antibiotic discovered in 1937 by L Whitby at May & Baker Ltd, so the compound was first called M&B 693, and was used during WW II for pneumonia. It was late superseded by penicillin and other sulfonamides. Sulfapyridine has been found to have antibacterial and anti-inflammatory activity and can be used in immunodeficiency research. Sulfapyridine can be used in an oxygen radical absorbance capacity (ORAC) where it scavenges peroxyl radicals. Formulations containing Sylfapyridine have been used for dermatological conditions and ulcerative colitis. The prodrug Sulfasalazine is composed of a molecule of Sulfapyridine and a molecule of 5-aminosalicylic acid (5-ASA) linked by an azo bond.
Sulfapyridine Sodium is freely soluble in water.

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Background

Sulfapyridine inhibits folic acid synthesis by acting as a competitive inhibitor of dihydropteroate synthetase, an enzyme found in the folic acid synthesis pathway.