Sugammadex Sodium

- Overview
  - Sugammadex Sodium is the octasodium salt of Sugammadex. It is a synthetic derivative of gamma-cyclodextrin, discovered by Organon (Scotland). The compound acts as a reversal agent for neuromuscular blocking agents.
    
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    Background
    
    Sugammadex Sodium acts as a reversal agent for neuromuscular blocking agents (rocuronium and vecuronium). It forms a complex with the blocking agent, and reduces the amount of blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction. This compound is biologically inactive and does not bind to plasma proteins, and has no effect on human receptors.
- Properties
  - CAS Number
    
    343306-79-6
    
    Molecular Formula
    
    C72H104O48S8 • 8Na
    
    Molecular Weight
    
    2178.01
    
    Appearance
    
    White to off-white powder
    
    Solubility
    
    Soluble in water. Practically insoluble in ethanol, methanol, and DMF.
    
    Other Properties
    
    Source: Synthetic
    Purity Level: 97-102% (anhydrous basis)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Sugammadex tested negatively during in vitro bacterial reverse mutation assays (Ames test),and in vitro chromosomal aberration assays in human peripheral blood lymphocytes. Sugammadex treatment on delayed-rectifier K+ ion current was investigated in differentiated NSC-34 mouse motor neuron cell line, a model for investigating neuronal development and differentiation in vitro. It was found that it influence the amplitude and gating of the current, and its actions could contribute to functional activities of motor neurons. (Hsu et al, 2017).