Cefodizime Sodium

- Overview
  - Cefodizime Sodium is the sodium salt of Cefodizime, a third-generation aminothiazolyl cephalosporin. Cefodizime has broad-spectrum activity and is resistant to most beta-lactamases. It is used against the pathogens causing respiratory and urinary infections and gonorrhea. It has immunostimulatory effects and can enhance the response of neutrophils.
    
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    Background
    
    Cefodizime Sodium is bactericidal antibiotic that targets penicillin-binding proteins (PBPs) 1A/B, 2, and 3 resulting in death of the bacterial cell. Cefodizime Sodium is an immunomodulator, enhancing the killing and oxidative response of neutrophils. It can enhance the bactericidal activity of crude extracts of neutrophil granules. Cefodizime stimulated the bactericidal activity of human neutrophils.
- Properties
  - CAS Number
    
    86329-79-5
    
    Molecular Formula
    
    C20H18N6O7S4 ∙ 2Na
    
    Molecular Weight
    
    628.63
    
    Appearance
    
    White to off-white powder
    
    Solubility
    
    Freely soluble in water and DMSO.
    
    Other Properties
    
    Source: Synthetic
    Purity Level: 88.0-94.0%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: The in vitro effect of cefodizime (1-250 ug/ml) on host immune response was studied. It stimulated colony formation by granulocyte- monocyte progenitors . It enhanced the lymphocyte transformation reaction was observed in a dose-dependent manner. It had no effect on antibody-dependent cell cytotoxicity or natural killer cell-mediated cytotoxicity or on the chemotactic activity of neutrophils. (Shin et al, 1996). Cefodizime stimulated the bactericidal activity of human neutrophils. It enhanced killing of bacteria, as seen in crude extracts of neutrophil granules, but does not universally alter the oxidative burst, suggesting that cefodizime and non 02-dependent killing systems of neutrophils cooperate in killing bacteria (Labro et al, 1987).
    
    Electrophoresis Applications: The influence of Cefodizime on primary cultures of human bronchial epithelial cells (HBEC) and their production of interleukin 8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Concentration series was 1, 10 and 100 mg/L. Cefodizime induced a dose-dependent increase in GM-CSF release but did not affect IL-8 or cytokine production (Pacheco et al, 1994).