7-Oxostaurosporine

- Overview
  - 7-Oxostaurosporine is the oxidised and highly fluorescent analogue of UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. 7-Oxostaurosporine possesses comparable activity against tumor cells lines to UCN-01. Despite its close relationship to UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties.
    
    7-Oxostaurosporine is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    
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    Background
    
    7-Oxostaurosporine inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells
- Properties
  - CAS Number
    
    141196-69-2
    
    Molecular Formula
    
    C28H24N4O4
    
    Molecular Weight
    
    480.5
    
    Appearance
    
    Yellow solid
    
    Storage
    
    -20°C
    
    * For research use only