Sodium Pyruvate

- Overview
  - Sodium Pyruvate is used by cells as a carbohydrate source. It is also involved the metabolism of amino acids, and initiates the Kreb's cycle. Pyruvate is the end product of glycolysis and is used in further metabolic cycles to supply cells with energy. It plays a role as a free radical scavenger and is a reactive oxygen species (ROS)-quencher. It can be used in cell culture applications and toxicity testing studies.
    Sodium Pyruvate is freely soluble in aqueous solution.
    
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    Background
    
    Pyruvate enters the Kreb's or Citric Acid Cycle in the presence of oxygen to supply cells with energy in the form of ATP (adenosine triphosphate). It acts as an intermediate in many metabolic pathways such as sugar metabolism.
- Properties
  - CAS Number
    
    113-24-6
    
    Molecular Formula
    
    C3H3NaO3
    
    Molecular Weight
    
    110.04
    
    Appearance
    
    White Crystalline Powder
    
    Solubility
    
    Freely soluble in water
    
    Other Properties
    
    PH: 5.1-7.0
    Assay: (Titration): ≥98.0%
    
    Storage
    
    Ambient
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Sodium Pyruvate is a common energy supplement in cell culture. It has antioxidant properties and protects against oxygen radicals. It was found to eliminate hydrogen peroxide and its toxic effects in human cell culture.
    In a study with bovine oocytes, Sodium Pyruvate can promote nuclear maturation, specifically cumulus-denuded oocytes (SDOs). When used in nonserum maturation medium, the compound supports (promotes) nuclear maturation and a continuous presence of cumulus cells during maturation is important for development of zygotes to the blastocyst stage.