Name: Sisomicin Sulfate
Price: 285.00 USD

- Overview
  - Sisomicin sulfate is a soluble broad-spectrum aminoglycoside antibiotic, and a dihydro analog of gentamicin C1a sulfate, Evopure. Sisomicin was first isolated in 1970 from Micromonopora inyoensis, a novel strain at the time, that was obtained from soil samples collected in the Inyo National Forest in California.
    
    Sisomicin sulfate is a bacterial protein synthesis inhibitor that binds to the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibiting translocation. It is effective against most strains of Klebsiellk spp., Escherichia coli, P. aeruginosa, Enterobacter and Proteus spp.. It is a potential treatment for conjunctiva. Sisomicin has been used in disk and tube dilution sensitivity tests.
    
    Sisomicin is generally more potent than gentamicin, and has show effective antibacterial synergy with beta-lactam antibiotics against a large range of bacteria.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
- Properties
  - Alternative Name
    
    Antibiotic 6640, Extramycin, Mensiso, Pathomycin, Sisomin, Rickamicin Sulfate, Ensamycin, Sch 13475
    
    CAS Number
    
    53179-09-2
    
    Molecular Formula
    
    C19H37N5O7 •2.5 H2SO4
    
    Molecular Weight
    
    692.72
    
    Appearance
    
    White to almost white powder
    
    Solubility
    
    Water: Soluble
    
    Other Properties
    
    Source: Micromonospora Inyoesis.
    PH: 3.5 - 5.5
    Assay: (On Dried Basis): Not less than 580 µg/mg
    Residue On Ignition: Not more than 1.0%
    Loss on Drying: Not more than 15.0%
    Melting Point: 70-73°C
    Optical Rotation: +100° to +110°
    Identification: Positive
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Sisomicin is a broad spectrum antibiotic which targets a wide range of gram positive and gram negative bacteria.
    
    Microbiology Applications: Sisomicin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Haemophilus influenzae 1.6 µg/mL – 3.1 µg/mLPseudomonas aeruginosa 2 µg/mL