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Overview
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Siomycin is a macrocyclic thiopeptide antibiotic with potent and selective antibacterial activity first isolated from the fermentation product of Streptomyces sioyaensis by Nishimura in 1959. This member of the thiostrepton family is a potent inhibitor of the oncogenic transcription factor, FoxM1. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kills transformed cells. Siomycin has anti-cancer properties.
Siomycin is soluble in DMF and DMSO.Please contact us at for specific academic pricing.
Background
Siomycin inhibits protein synthesis in bacteria by interfering with rRNA binding, specifically the 23S rRNA. The reduction in transcription activity is reflected in the down-regulation of protein and mRNA levels of the transcription factor Forkhead box family ( FoxM1) and effects on downstream genes, Cdc25B, survivin and CENPB.
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