Name: Nafamostat Mesylate
Price: 176.00 USD

- Overview
  - Nafamostat Mesylate is a synthetic serine protease inhibitor, inhibiting a number of Lys/Arg-specifc serine proteinases. It is a tryptase inhibitor. It is an anticoagulant. proventing the proteolysis of fibrinogen into fibrin. The compound has anti-viral, anti-inflammatory, and anti-cancer properties.
    Nafamostat Mesylate has potential for COVID-19 research as it has potent in vitro anti-viral inhibitor in lung cells. A number of phase 2 and 3 clinical trials are underway in several countries.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Anti-viral activity is via inhibition of serine protease, which is required for the host membrane fusion of viral envelope protein. Its anti-inflammatory properties are to to the significantly inhibition of the release of platelet beta-thromboglobulin.
- Properties
  - CAS Number
    
    82956-11-4
    
    Molecular Formula
    
    C19H17N5O2 · 2CH4O3S
    
    Molecular Weight
    
    539.58
    
    Appearance
    
    White crystalline powder
    
    Other Properties
    
    Source: Synthetic
    Identification: Passes test
    Purity Level: 99.0% - 101.0%
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Anti-viral activity against MERS-CoV, influenza virus, and SARS-CoV-2. Also effective against obligate intracellular bacterium Chlamydia trachomatis.
    
    Microbiology Applications: During in vitro studies, the compound is effective with MERS-CoV, influenza virus, and SARS-CoV-2. A quantitative fusion assay dependent on SARS-CoV-2 S protein, angiotensin I convertin enzyme 2 (ACE2 and TMPRSS2, and found that the compound inhibitied the fusion. Nafamostat Mesylate blocked SARS-CoV-2 infection of Calu-3 cells with an effective concentration (EC)50 around 10 nM in a cell-type-dependent manner (Yamamoto et al, 2020).
    
    Eukaryotic Cell Culture Applications: Nafamostat Mesylate inhibits chlamydial intracellular growth in cell culture and reduced both the inclusion size and number in cell culture. Nafamostat mesylate mainly inhibits reticulate body replication (Peng et al, 2020).