Name: Colistin Sulfate, EP
Price: 161.00 USD

- Overview
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    Background
    
    Colistin Sulfate displaces essential ions (magnesium and calcium) in the lipopolysaccharide layer of the cell wall leading to local disturbance of the outer membrane, which causes increased permeability and eventually cell lysis. Colistin also has anti-endotoxin activity. The endotoxin of Gram-negative bacteria is the lipid A portion of the lipopolysaccharide molecules, and colistin binds and neutralizes the lipolysaccharide (Falagas et al, 2005).
- Properties
  - CAS Number
    
    1264-72-8
    
    Molecular Formula
    
    C53H100N16O13 • xH2SO4 (Colistin Sulfate A)
    
    Molecular Weight
    
    1155.43 (Colistin Sulfate A)
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    water (50 mg/ml)
    
    Other Properties
    
    PH: 4.0 – 6.0
    Loss on Drying: Not more than 3.5%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Colistin Sulfate is used primarily against Gram-negative bacteria.
    
    Microbiology Applications: Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Colistin has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    Shigella spp. 64 µg/mL -128 µg/mL
    Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL
    Media Supplement
    Colistin is routinely used as a selection agent in several types of isolation media:
    Columbia Blood Agar - Campylobacter selective supplement (Butzler)
    Columbia Blood Agar - Staphylococcus/Streptococcus selective supplement
    Columbia Blood Agar - Streptococcus Selective Supplement
    Listeria Selective Agar - Listeria Selective Supplement
    Listeria Selective Agar - Modified Listeria Selective Supplement
    
    Plant Biology Applications: Plasmodiophora brassicae spores were treated with Colistin Sulfate and used to inoculate hairy roots of cabbage, Chinese cabbage, turnip, and rape in a useful dual culture system for P. brassicae (Asano et al, 1999).