Name: Colistin Sodium Methanesulfonate
Price: 280.00 USD

- Overview
  - Colistin Sodium Methanesulfonate is considered an inactive prodrug of Colistin, which means it is inactive until converted into Colistin by cellular enzymes. It is prepared by the reaction of Colistin with formaldehyde, followed by sodium bisulfate. It is also less potent and less toxic than Colistin Sulfate and is effective against Gram-negative bacteria. Colistin works by targeting the bacterial cell membrane, leading to reduced permeability and cell death. The product has been explored with renewed interest as a possible anti-tuberculosis effects.
    
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    Background
    
    THe mechamism of action of Colistin Methanesulfonate has not been fully expllored, and has only been described from a histological and genomics perspective. Researchers used a GCxGC-TOFMS metabolomics approach and found that the prdouct acts by disrupting the cell wall of Mycobacteria.
- Properties
  - CAS Number
    
    8068-28-8
    
    Molecular Formula
    
    C58H115N16Na5O28S5
    
    Molecular Weight
    
    1759.90
    
    Appearance
    
    White to slightly yellow fine powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Bacillus polymyxa
    PH: 6.5-8.5
    Assay: ≥390 µg/mg
    Heavy Metals: ≤20 ppm
    Loss on Drying: ≤5.0%
    Optical Rotation: -46° to -51°
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Colistin primarily targets and disrupts the cell wall of Gram negative bacteria and Mycobacteria.
    
    Microbiology Applications: Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    Shigella spp. 64 µg/mL -128 µg/mL
    Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL