Polymyxin B1 Sulfate, EvoPure®

Polymyxin B1 Sulfate, EvoPure®

Catalog Number:
PB01342637TOK
Mfr. No.:
TOK-P037
Price:
$962
  • Size:
    10 mg
    Quantity:
    Add to Cart:
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      • Overview

        • Polymyxin B1 Sulfate, EvoPure® is one of the polypeptide fractions in Polymyxin B Sulfate. The fatty acid group found in Polymyxin B1 Sulfate is 6-methyloctanoic acid (6-MOA); the same group found in Polymyxin B1-I Sulfate. Polymyxin B1 however, contains a L-leucine residue, rather than the L-isoleucine reside found in Polymyxin B1-I sulfate. Results from in vitro studies have shown marginal differences in MIC data when comparing the fractions.

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          Background

          Polymyxin B targets and alters the permeability of lipopolysaccharide (LPS) of Gram-negative bacteria leading to cell lysis. Polymyxin B only needs to interact with LPS, it is not required to enter the cell.

      • Properties
        • CAS Number
          4135-11-09
          Molecular Formula
          C56H98N16O13 · xH2SO4 (lot specific)
          Molecular Weight
          1203.47 g/mol (Free base)
          Appearance
          White powder
          Other Properties
          Source: Pseudomonas sp.
          Purity Level: >90.0%
          Storage
          -20°C

          * For research use only

      • Applications
        • Application Description
          Spectrum: Polymyxin B Sulfate targets the outer membrane of Gram-negative bacteria especially Pseudomonas aeruginosa.

          Microbiology Applications: Polymyxin B Sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
          Pseudomonas aeruginosa 0.25 µg/mL – 1 µg/mL

          Plant Biology Applications: Polymyxin was successfully tested to counteract phytopathogenic Gram-negative bacteria growth. Polymyxin reduced growth of different strains of Pseudomonas viridiflava at low concentrations (0.08 µg/ml) whereas Erwinia carotovora growth was inhibited at slightly higher concentrations (0.25 µg/ml) (Selim et al, 2005).
    MSDS

    Documents

    MSDS-EU

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