Name: Polymyxin B1-I Sulfate, EvoPure®
Price: 761.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Polymyxin B targets and alters permeability lipopolysaccharide (LPS) of Gram negative bacteria leading to lysing of the cell. Polymyxin B only needs to interact with LPS, it is not required to enter the cell.
- Properties
  - CAS Number
    
    80469-10-9
    
    Molecular Formula
    
    C56H98N16O13 • xH2O4S (lot specific)
    
    Molecular Weight
    
    1203.47 g/mol (Free base)
    
    Appearance
    
    White powder
    
    Other Properties
    
    Source: Pseudomonas sp.
    Purity Level: ≥90.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Polymyxin B sulfate targets the outer membrane of Gram-negative bacteria especially Pseudomonas aeruginosa.Polymyxin B3 was the most active polymyxin fraction according to research done by Kassamali et al, and there was a synergistic effect using Polymyxin B3 and B1-I (Kassamali et al, year)
    
    Microbiology Applications: Polymyxin B Sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Pseudomonas aeruginosa 0.25 µg/mL – 1 µg/mL
    
    Plant Biology Applications: Polymyxin B sulfate was successfully tested to counteract phytopathogenic Gram-negative bacterial growth including different strains of Pseudomonas viridiflava and Erwinia carotovora. Polymixin B sulfate was shown to reduce bacterial growth of different strains of Pseudomonas viridiflava at low concentrations, (0.08 µg/ml) and Erwinia carotovora growth at slightly higher concentrations (0.25 µg/ml) (Selim et al. 2005).