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Overview
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Background
Placenta Growth Factor-2 (PLGF-2) is an angiogenic factor produced in umbilical vein endothelial cells and placenta. PLGF-2 plays important roles in angiogenesis and endothelial cell growth. PLGF-2 signals through the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation and migration. PLGF-2 also signals through Neuropilin (NP-1) in a heparin-dependent manner.
Recombinant human PLGF-2 is produced in E. coli as a homodimer containing 2 × 153 amino acids and having a total molecular mass of 36 kDa.
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