BmrA Transporter

- Overview
  - CALIXAR’s BmrA transporter (Bacilus subtilis multidrug resistance ABC transporter ATP-binding Protein) is an efflux protein and ABC transporter that acts as a mechanical pump for ATP dependent drug efflux. This unique characteristic makes BmrA transporters a powerful therapeutic target for multi-drug resistance studies.
    
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    Background
    
    CALIXAR’s BmrA Transporters aid in the exploration, improvement, validation of novel molecules and therapeutic antibodies. Our BmrA transporters are excellent for therapeutic indications such as bacterial resistance to antibiotics.
    
    More Details
    
    CALIXAR
    
    Purified Membrane Proteins
- Properties
  - Source
    
    Bacillus subtilis
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Immobilized Metal Affinity Chromatography (Pruity: >90%)
    
    Formulation
    
    50mM Tris-Cl pH 8.0, 100 mM NaCl, 0.01% DDM, 10%glycerol as sample buffer
    
    Storage
    
    Store at -80°C
    
    Concentration
    
    Up to 5mg/ml
    
    Molecular Weight
    
    64.5 kDa
    
    Class
    
    Membrane Proteins
    
    Expression system
    
    Escherichia coli ( BL21C43)
    
    Sequence
    
    Full-length, wildtype sequence, with a N-terminus 6xHis-tag.
    
    Activity
    
    Confirmed by ATPase activity assay
    
    More Information
    
    UniProt
    
    O06967
    
    * For Research Use Only
- Applications
  - Application Description
    
    CALIXAR’s BmrA transporter (Bacilus subtilis multidrug resistance ABC transporter ATP-binding Protein) is an efflux protein and ABC transporter that acts as a mechanical pump for ATP dependent drug efflux. This unique characteristic makes BmrA transporters a powerful therapeutic target for multi-drug resistance studies.
- Reference
  - Novel systematic detergent. Desuzinges Mandon E. et al. 2017
    Structuring detergents for extracting and stabilizing functional membrane proteins. Matar-Merheb R. et al. 2011

Datasheet

BmrA transporters are powerful therapeutic targets for multi-drug resistance studies, ideal for therapeutic indications such as bacterial resistance to antibiotics.

BmrA Transporter

Background

More Details

More Information

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