AcrB Transporter

- Overview
  - CALIXAR’s AcrB transporter (Acriflavine resistance Protein B) is a bacterial multidrug exporter that aids in the identification, development, refinement, and validation of new molecules and therapeutic antibodies. Our AcrB transporters are exemplary for therapeutic indications such as bacterial resistance to antibiotics.
    
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    Background
    
    Acriflavine resistance Protein B (AcrB) is a bacterial multidrug exporter. AcrB is a good target for indications of bacterial resistance. Protein has a C-terminal 6X His tag.
    
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    CALIXAR
    
    Purified Membrane Proteins
- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Immobilized Metal Affinity Chromatography (Pruity: >95%)
    
    Formulation
    
    25mM Na2HPO4, 100mM NaCl, 0.01% DDM as sample buffer
    
    Storage
    
    Store at -80°C
    
    Concentration
    
    Up to 5mg/ml
    
    Molecular Weight
    
    114.6 kDa
    
    Class
    
    Membrane Proteins
    
    Expression system
    
    Escherichia coli ( BL21C43)
    
    Sequence
    
    Full-length, wildtype sequence, with a C-terminus, 6xHis-tag
    
    Activity
    
    Confirmed by ligand binding
    
    More Information
    
    UniProt
    
    P31224
    
    * For Research Use Only
- Applications
  - Application Description
    
    CALIXAR’s AcrB transporter (Acriflavine resistance Protein B) is a bacterial multidrug exporter that aids in the identification, development, refinement, and validation of new molecules and therapeutic antibodies.
- Reference
  - Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Eicher T. et al. 2012
    Purification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein. Pos KM. et al. 2002

Datasheet

AcrB efflux pump membrane transporters are powerful therapeutic targets especially in the treatment of such conditions as bacterial resistance to antibiotics.

AcrB Transporter

Background

More Details

More Information

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