Name: Pirlimycin Hydrochloride
Price: 320.00 USD

- Overview
  - Pirlimycin Hydrochloride is the hydrochloride salt form of Pirlimycin, a semi-synthetic tetracycline analog and derivative of clindamycin, a broad-spectrum antibiotic belonging to the lincosamide family, which has activity against anaerobes and protozoa. The hydrochloride salt forms at the basic pipercolic acid moiety.
    Pirlimycin Hydrochloride is soluble in ethanol, methanol, DMF and DMSO.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Pirlimycin inhbits bacterial protein synthesis by binding to the 50S ribosomal subunit and thereby inihibiting peptidyl transferase.
- Properties
  - CAS Number
    
    78822-40-9
    
    Molecular Formula
    
    C17H31Cl1N2O5S • HCl
    
    Molecular Weight
    
    447.42
    
    Appearance
    
    White solid
    
    Solubility
    
    Soluble in water, ethanol, methanol, DMSO and DMF
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Pirlimycin Hydrochloride is active against Gram-positive bacteria including Staphylococcus, Streptococcus, Bacterioides, and Plasmodium. It is also active against anaerobic bacteria and protozoa.
    
    Microbiology Applications: In vitro activity of Pirlimycin Hydrochloride and its primary metabolite, Pirlimycin sulfoxide, was investigated. Lowest MIC50 was observed in Bifidobacterium spp. and Eubacterium spp. (0.06 µg/ml). Pirlimycin sulfoxide was less active, with lowest MIC50 of 1 µg/ml in EUbacterium spp. Therefore, the parent compound showed a 16-fold higher antimicrobial activity comparied to Pirlimycin Sulfoxide.
    Pirlimycin Hydrochloride is the active component of Pirsue, an aqueous gel given via intramammary infusion to treat mastitis in lactating dairy cattle. Microbiological investigation can be evaluated for the antimicrobial effectiveness against different groups of bacteria. Several studies have found in vitro resistance to Pirlimycin.
    ELISA-based detection for food safety protocols have been developed for beef, milk, and honey samples. Pirlimycin is the marker residue in milk.