pAAVone-AAV2-Retro-CMV-mCherry

pAAVone-AAV2-Retro-CMV-mCherry is a plasmid used to produce AAV2-Retro-CMV-mCherry using novel AAVone production system. It integrates all the AAV production necessary components, including Ad helper genes (E2A, E4orf6 and VA RNA), AAV helper genes (Rep and AAV2-Retro Cap), and a single-strand AAV-CMV-mCherry genome. AAV2-Retro-CMV-mCherry viruses can be simply and efficiently produced by transfection of this single-into host cells, such us HEK 293 and HEK 293T. AAV2-Retro (often referred to simply as AAV-Retro) is a modified version of the AAV2 serotype that was engineered to efficiently transduce neurons and other cells in a retrograde manner. This means that AAV2-Retro can travel from the axon terminals of neurons back to their cell bodies, enabling highly efficient gene delivery across neural circuits. It was developed to overcome the limitations of traditional AAV serotypes that are less efficient at crossing synapses and spreading through neural networks.

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