pAAVdual-Myog-EGFP

pAAVdual-Myog-EGFP is used to produce AAV-Myog-EGFP virus using novel AAVdual production system. In this plasmid, the regular single strand AAV genome with a Myog promoter and an EGFP reporter is cloned into our novel Ad helper plasmid, mini-pHelper. AAV-Myog-EGFP viruses can be generated by co-transfection of this plasmid with regular AAV helper (pRCap) plasmids, carrying AAV2 rep gene and different cap genes, without adding additional Ad helper plasmid to supply E2A, E4orf6 and VA RNA functions.
The Myog promoter refers to the promoter region of the Myogenin (Myog) gene, which plays a critical role in muscle development, particularly in the differentiation of skeletal muscle cells (myogenesis). Myogenin is a member of the myogenic regulatory factors (MRFs), a group of transcription factors essential for muscle cell differentiation. The Myog promoter is a muscle-specific regulatory element that drives gene expression during the differentiation of skeletal muscle cells. It is a vital tool in muscle development research, gene therapy for muscle diseases, and the creation of transgenic models to study myogenesis and muscle function. Its specificity to muscle tissue, particularly during development, makes it invaluable for targeting gene expression in studies focused on skeletal muscle formation and regenerative medicine.

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