pAAVdual-Ins2-EGFP

pAAVdual-Ins2-EGFP is used to produce AAV-Ins2-EGFP virus using novel AAVdual production system. In this plasmid, the regular single strand AAV genome with a Ins2 promoter and an EGFP reporter is cloned into our novel Ad helper plasmid, mini-pHelper. AAV-Ins2-EGFP viruses can be generated by co-transfection of this plasmid with regular AAV helper (pRCap) plasmids, carrying AAV2 rep gene and different cap genes, without adding additional Ad helper plasmid to supply E2A, E4orf6 and VA RNA functions.
The Ins2 promoter refers to the promoter region of the Insulin 2 (Ins2) gene, primarily studied in rodents such as mice and rats. The Ins2 gene encodes a precursor of insulin, which is a crucial hormone in regulating blood glucose levels. The Ins2 promoter is commonly used in research to drive the expression of transgenes specifically in pancreatic beta cells, where insulin is naturally produced. The Ins2 promoter is highly specific to pancreatic beta cells. This makes it a valuable tool in research focused on diabetes, insulin production, and pancreatic function

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