Neomycin Sulfate, USP

Name: Neomycin Sulfate, USP
Price: 184.00 USD

Catalog Number:

PB01342490TOK

Mfr. No.:

TOK-N003

Price:

$184

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- Overview
  - Neomycin Sulfate, USP is a broad-spectrum aminoglycoside antibiotic composed of related compounds including Neomycin A (neamine), Neomycin B (framycetin), Neomycin C, and a few minor compounds. Neomycin B is the most active fraction, followed by C and A. The quantities of these components vary from lot to lot.
    
    Neomycin Sulfate, USP conforms to United States Pharmacopoeia specifications.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
- Properties
  - CAS Number
    
    1405-10-3
    
    Molecular Formula
    
    C23H46N6O13 · 3 H2SO4
    
    Molecular Weight
    
    908.88
    
    Appearance
    
    White or yellowish powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Streptomyces fradiae
    PH: 5.0-7.5
    Assay: (Dry basis): ≤ 600µg/mg
    Loss on Drying: ≤ 8.0%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Neomycin is broad-spectrum, but is mostly used against Gram-negative bacteria.
    
    Microbiology Applications: Neomycin can be used for gene selection, via exploiting the resistance gene (NPT II) (Aragão, 2009).
    Neomycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative effective ranges include:
    
    Pseudomonas aeruginosa 0.5 µg/mL – 64 µg/ml
    Haemophilus influenzae 1.6 µg/mL – 6.3 µg/ml
    
    Neomycin Sulfate can also be used for food testing in TSN agar to select for Clostridium perfringins and inhibit growth of Enterobacteria and Clostridium bifermentans.
    
    Plant Biology Applications: Neomycin is commonly used in gene selection wtih Agrobacterium transformation protocols to select for plants that have taken up the plasmid conferring resistance to Neomycin.
    
    Eukaryotic Cell Culture Applications: Neomycin is routinely used to select for cells containing resistance plasmids such as pcDNA3 in cell lines including AtT-20. For additional information, please visit our cell culture database.