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Overview
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Moxidectin is a semi-synthetic antiparasitic agent belonging to the the macrocyclic lactone (LC) family, and milbemycin sub-family. It is derived from nemadectin by selective oxidation followed by methyloximation. Nemadectin is a fermentation product of the bacterium Streptomyces cyanogriseus subsp. noncyanogenus. It targets glutamate-gated chloride channels (GluCls) of the parasite. It was patended in 1991 as an anthelmintic for internal parasite control. It is also used in veterinary research and crop pest control. it exhibits low toxicity to the host and low ecotoxicity. The presence of methyloxime affords Moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin.
Moxidectin is soluble in ethanol, methanol, DMF and DMSO. It is insoluble in water.Please contact us at for specific academic pricing.
Background
Moxidectin binding increases target GluCl permeability, resulting in an influx of chloride ions and dysfunction of the excretory pore, flaccid paralysis of neuromuscular systems, and death of the nematode and arthropods via host response.
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