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Camptothecin (Camptotheca acuminata)

Camptothecin (Camptotheca acuminata)

Catalog Number:

CR04341416TOK

Mfr. No.:

TOK-C070

Price:

$192

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- Overview
  - Camptothecin is an alkaloid topoisomerase l (topo l) inhibitor with anticancer properties. Camptothecin is isolated from Camptotheca acuminata, a deciduous tree.
    
    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Camptothecin inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis.
- Properties
  - CAS Number
    
    7689-03-4
    
    Molecular Formula
    
    C20H16N2O4
    
    Molecular Weight
    
    348.352
    
    Other Properties
    
    Source: Camptotheca acuminata (plant)
    Assay: Not less than 99.0%
    Residue On Ignition: Not more than 0.3%
    Loss on Drying: Not more than 1.0%
    Identification: Passes test
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability.

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