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Camptothecin (Camptotheca acuminata)

Camptothecin (Camptotheca acuminata)

Catalog Number:
CR04341416TOK
Mfr. No.:
TOK-C070
Price:
$180
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      • Overview

        • Camptothecin is an alkaloid topoisomerase l (topo l) inhibitor with anticancer properties. Camptothecin is isolated from Camptotheca acuminata, a deciduous tree.

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          Background

          Camptothecin inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis.

      • Properties
        • CAS Number
          7689-03-4
          Molecular Formula
          C20H16N2O4
          Molecular Weight
          348.352
          Other Properties
          Source: Camptotheca acuminata (plant)
          Assay: Not less than 99.0%
          Residue On Ignition: Not more than 0.3%
          Loss on Drying: Not more than 1.0%
          Identification: Passes test
          Storage
          2-8 °C

          * For research use only

      • Applications
        • Application Description
          Cancer Applications: Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability.
    Datasheet
    MSDS

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