Milbemycin A3 oxime

- Overview
  - Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections.
    
    Milbemycin A3 oxime is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    
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    Background
    
    Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
- Properties
  - CAS Number
    
    114177-14-9
    
    Molecular Formula
    
    C31H43NO7
    
    Molecular Weight
    
    541.7
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only