Mezlocillin Sodium

- Overview
  - Mezlocillin Sodium is broad-spectrum, semisynthetic, β-lactam antibiotic and ureido penicillin derived from ampicillin. It is sparingly soluble in aqueous solution.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid-encoded β-lactamases, however, Mezlocillin is resistant to a number of β-lactamases.
- Properties
  - CAS Number
    
    59798-30-0
    
    Molecular Formula
    
    C21H24N5NaO8S2
    
    Molecular Weight
    
    561.57
    
    Appearance
    
    White to off-white crystalline powder
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤6.0%
    PH: 4.5-8.0
    Assay: (On Dried Basis): 838-978 µg/mg
    Optical Rotation: +175° to +195°
    Identification: Passes test
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Mezlocillin is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria.
    
    Microbiology Applications: Mezlocillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Helicobacter pylori 0.125 µg/mL – 0.25 µg/mL
    
    Eukaryotic Cell Culture Applications: Mezlocillin did not cause any cytotoxicity in cell cultures of mouse sarcoma L-1, human lung cancer E-14, or human malignant melanoma MEW (Roszkowski et al, 1984).