Name: Mca-KPLGL-Dap(Dnp)-AR-NH2
Price: 298.00 USD

- Overview
  - FRET substrate for matrix metalloproteinases.
    Mca-KPLGL-Dap(Dnp)-AR-NH2 is a broad spectrum fluorogenic FRET substrate suitable for matrix metalloproteinases including intestinal collagenase (MMP-1), neutrophil collagenase (MMP-8) collagenase 3 (MMP-13), gelatinase A (MMP-2), gelatinase B (MMP-9), matrilysin (MMP-7) and MMP-17. Mca-KPLGL-Dap(Dnp)-AR-NH2 is cleaved very poorly by neutrophil elastase, and not at all by trypsin. Mca-KPLGL-Dap(Dnp)-AR-NH2 was obtained by the addition of an N-terminal lysine to Mca-PLGL-Dap(Dnp)-AR-NH (PS-040) which improves substrate properties. It contains the highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group. Mca-KPLGL-Dap(Dnp)-AR-NH2 is fully water soluble and allows measurement of metalloproteinase activity in tissue culture conditions such as on the surface of cells.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Fluorescent Labelled Peptides
    
    Molecular Formula
    
    C55H80N16O16
    
    Molecular Weight
    
    1221.3
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble as a stock solution in DMSO
    
    Other Properties
    
    Sequence: Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2,Mca-KPLGLX(Dnp)AR-NH2
    Modification: 7-methoxycoumarin (Mca) at the N terminal, X is diaminopropionic acid substituted with 2,4-dinitrophenyl (Dnp), C terminal amide
    
    Storage
    
    Store desiccated, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Mca-KPLGL-Dap(Dnp)-AR-NH2

Mca-KPLGL-Dap(Dnp)-AR-NH2

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