Name: Mca-RPPGFSAFK(Dnp)-OH
Price: 298.00 USD

- Overview
  - FRET substrate for endothelin-converting enzyme-1 (ECE-1).
    Mca-RPPGFSAFK(Dnp)-OH, also known as Mca-(Ala7,Lys(Dnp)9)-bradykinin is a very sensitive fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), the membrane-bound zinc metallopeptidase that is related to neprilysin. Mca-RPPGFSAFK(Dnp)-OH can also be used for assaying ACE1, ACE2, BACE, cathepsin A, cathepsin X/Z, ECE-1, ECE-2, MMP-2, MMP9, neprilysin, insulinase and thermolysin (TLN), although it is not a substrate for MMP1. Mca-RPPGFSAFK(Dnp)-OH substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group.
    
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- Properties
  - Categories
    
    Fluorescent Labelled Peptides
    
    Alternative Name
    
    Mca-(Ala7,Lys(Dnp)9)-bradykinin
    
    Molecular Formula
    
    C66H81N15O19
    
    Molecular Weight
    
    1388.5
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in DMSO
    
    Other Properties
    
    Sequence: Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp),Mca-RPPGFSAFK(Dnp)
    Modification: 7-methoxycoumarin (Mca) at the N terminal, Lysine 9 has 2,4-dinitrophenyl (Dnp) attached
    
    Storage
    
    Store desiccated, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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