Lappaconitine - Amerigo Scientific

- Overview
  - Traditionally used for pain relief, lappaconitine is a plant-derived C18-diterpenoid alkaloid. The molecular structure of lappaconitine was first reported in 1895. In rats, the antinociceptive action of lappaconitine has been shown to be based on the enhanced expression of dynorphin A in the spinal microglia. Lappaconitine hydrobromide is clinically used to reduce swelling and inflammation while providing a local anesthetic effect.
    
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- Properties
  - CAS Number
    
    32854-75-4
    
    Molecular Formula
    
    C32H44N2O8
    
    Molecular Weight
    
    584.7 g/mol
    
    MDL Number
    
    MFCD03424256
    
    Note
    
    There is a hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Sun et al (2018). Lappaconitine, a C18-diterpenoid alkaloid, exhibits antihypersensitivity in chronic pain through stimulation of spinal dynorphin A expression. Psychopharmacology 235:2559–2571.
    Yu et al (2000). Clinical application of Lappaconitine hydrobromide. Academic Journal of Second Military Medical University 7.
    Zeng et al (2020). The 1α-hydroxy-A-rings of norditerpenoid alkaloids are twisted-boat conformers. RSC Advance 10:18797-18805.