Name: Lappaconitine Hydrobromide
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- Overview
  - Hydrobromide form of lappaconitine, lappaconitine hydrobromide is clinically used to reduce swelling and inflammation while providing a local anesthetic effect. The molecular structure of lappaconitine was first reported in 1895. Traditionally used for pain relief, lappaconitine is a plant-derived C18-diuterpenoid alkaloid. In rats, the antinociceptive action of lappaconitine has been shown to be based on the enhanced expression of dynorphin A in the spinal microglia.
    
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- Properties
  - Categories
    
    Alkaloids
    
    CAS Number
    
    97792-45-5
    
    Molecular Formula
    
    C32H44N2O8·HBr
    
    Molecular Weight
    
    665.61 g/mol
    
    MDL Number
    
    MFCD00171334
    
    Note
    
    There is a hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Sun et al (2018). Lappaconitine, a C18-diterpenoid alkaloid, exhibits antihypersensitivity in chronic pain through stimulation of spinal dynorphin A expression. Psychopharmacology 235:2559–2571.
    Yu et al (2000). Clinical application of Lappaconitine hydrobromide. Academic Journal of Second Military Medical University 7.
    Zeng et al (2020). The 1α-hydroxy-A-rings of norditerpenoid alkaloids are twisted-boat conformers. RSC Advance 10:18797-18805.