Dirithromycin - Amerigo Scientific

- Overview
  - Dirithromycin is a macrolide antibiotic pro-drug of 9S-erythromycylamine, a close analogue of erythromycin in which the 9-keto group is replaced with an amino group in the S-configuration. Although erythromycylamine overcomes the acid instability of erythromycin, it is poorly absorbed following oral administration. Dirithromycin is formed by reacting erythromycylamine with an aldehyde to form a Schiff base which undergoes cyclisation to an oxazine with the C11-alcohol. Dirithromycin provides higher tissue levels and prolonged in vivo half-life by slowly releasing erythromycylamine.
    
    Dirithromycin is soluble in ethanol, methanol, DMF and DMSO.
    
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- Properties
  - CAS Number
    
    62013-04-1
    
    Molecular Formula
    
    C42H78N2O14
    
    Molecular Weight
    
    835.1
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only