Hyaluronic Acid Sodium - Amerigo Scientific

- Overview
  - Hyaluronic Acid Sodium is the sodium salt form of Hyaluronic acid, an anionic anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions. One of the chief components of the extracellular matrix, Hyaluronic acid contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.
    
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- Properties
  - CAS Number
    
    9067-32-7
    
    Molecular Formula
    
    (C14H21NaNO11)n
    
    Molecular Weight
    
    ≥2 MDa
    
    Appearance
    
    White powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Synthetic
    PH: (0.5% in H2O)5.5-7.5
    Loss on Drying: ≥10.0%
    
    Storage
    
    -20 °C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Ethanol impairs collagen metabolism in human skin fibroblasts, leading to a decrease in the amount of produced protein. Hyaluronic acid had a protective effect on the disturbances caused by ethanol as shown by cultured human skin fibroblasts (Donejko et al, 2015). Bovine articular chondrocytes were encapsulated by a composite hydrogel derived from water-soluble chitosan and oxidized hyaluronic acid. The hydrogen supported cell survival and cells retained their chrondrocytic morphology. This characteristic provides a potential opportunity to use the composite hydrogels in tissue engineering applications (Tan et al, 2009). Hyaluronic acid promoted micgration of human corneal epithelial cells in vitro. The effect is likely to be related to rapid migration of cells leading to wound closure, likely facilitated by the adhesion between CD44 (a cell surface adhesion molecule) and hyaluronic acid, which coats the surface of the cornea (Gomes et al 2004).

Datasheet

MSDS

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