Name: Nalidixic Acid Sodium
Price: 146.00 USD

- Overview
  - Nalidixic Acid Sodium is a synthetic naphthyridone antibiotic developed by Sanofi Aventis. It is similar in structure and mechanism to quinolones, with a 1,8-naphthyridine nucleus containing 2 nitrogen atoms (unlike quinoline that contains a single nitrogen atom). It is an inhibitor of bacterial DNA polymerase and avian myeloblastoma virus reverse transcriptase. The compound can be used to study bacterial division and apoptosis research. Nalidixic Acid Sodium is sparingly soluble in water.
    
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    Background
    
    Nalidixic Acid indirectly inhibits protein synthesis by binding DNA and interfering with enzymes involved in DNA replication and transcription. In a study with avian myeloblastosis virus RT activity, the presence of adenine in the template made for more efficient inhibition
- Properties
  - CAS Number
    
    3374-05-8
    
    Molecular Formula
    
    C12H11N2NaO3
    
    Molecular Weight
    
    254.22
    
    Solubility
    
    Sparingly soluble in water
    
    Other Properties
    
    Source: Synthetic
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Nalidixic Acid is a broad-spectrum antibiotic with activity against Gram-negative and Gram-positive bacteria. The action is primarily bacteriostatic at low levels, and bactericidal at higher concentrations. It is commonly used against bacteria responsible for urinary tract infections.
    
    Microbiology Applications: Nalidixic Acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    E. coli 2 µg/mL - 8 µg/mLProteus mirabilis 2.1 µg/mL - 8 µg/mL