Name: Human TLR5 full length protein-synthetic nanodisc
Price: 1013.00 USD

- Overview
  - Target: TLR5
    Tag: C-Flag Tag
    Synonyms: MELIOS; SLE1; SLEB1; TIL3
    Protein Families: Druggable Genome, Transmembrane
    Protein Pathways: Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway
    
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    Background
    
    Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
- Properties
  - Type
    
    Synthetic Nanodiscs
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
    
    Storage
    
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    
    Molecular Weight
    
    The human full length TLR5 protein has a MW of 97.8 kDa
    
    Expression system
    
    HEK293
    
    More Information
    
    UniProt
    
    O60602
    
    * For research use only.

MSDS

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Datasheet

Human TLR5 full length protein-synthetic nanodisc

Human TLR5 full length protein-synthetic nanodisc

Background

More Information

Documents

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