Name: Human TLR2 full length protein-synthetic nanodisc
Price: 1013.00 USD

- Overview
  - Target: TLR2
    Tag: C-Flag Tag
    Synonyms: CD282; TIL4
    Protein Families: Druggable Genome, Transmembrane
    Protein Pathways: Toll-like receptor signaling pathway
    
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    Background
    
    The protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the hosts inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
- Properties
  - Type
    
    Synthetic Nanodiscs
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
    
    Storage
    
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    
    Molecular Weight
    
    The human full length TLR2 protein has a MW of 89.8 kDa
    
    Expression system
    
    HEK293
    
    More Information
    
    UniProt
    
    O60603
    
    * For research use only.

MSDS

Documents

Datasheet

Human TLR2 full length protein-synthetic nanodisc

Human TLR2 full length protein-synthetic nanodisc

Background

More Information

Documents

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