Name: Human TLR4 full length protein-synthetic nanodisc
Price: 1013.00 USD

- Overview
  - Target: TLR4
    Tag: C-Flag Tag
    Synonyms: ARMD10; CD284; TLR-4
    Protein Families: Druggable Genome, Transmembrane
    Protein Pathways: Toll-like receptor signaling pathway
    
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    Background
    
    The protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration.
- Properties
  - Type
    
    Synthetic Nanodiscs
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
    
    Storage
    
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    
    Molecular Weight
    
    The human full length TLR4 protein has a MW of 95.7 kDa
    
    Expression system
    
    HEK293
    
    More Information
    
    UniProt
    
    O00206
    
    * For research use only.

MSDS

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Datasheet

Human TLR4 full length protein-synthetic nanodisc

Human TLR4 full length protein-synthetic nanodisc

Background

More Information

Documents

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