Name: GT1b-Ganglioside sodium
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- Overview
  - GT1b (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b is one of the major gangliosides in neuronal and glial membranes, it interacts with the myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishik,i 1996), as well as for viruses, a few examples include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAc;GT1b-Ganglioside
    
    CAS Number
    
    59247-13-1
    
    Molecular Formula
    
    C95H165N5O48·xNa
    
    Molecular Weight
    
    2,145.33 g/mol
    
    MDL Number
    
    MFCD00081622
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
    Nishiki et al (1996) The high‐affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a, Febs Letters, 378(3), 253-257
    Low et al (2006) Identification of Gangliosides GD1b and GT1b as Receptors for BK Virus, Journal of Virology, 80(3), 1361-1366