Name: Gangliotetraose
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- Overview
  - Gangliotetraose (Galβ1,3GalNAcβ1,4Galβ1,4Glc) is the core tetrasaccharide found in many gangliosides, such as, GM1 (Ledeen, 2009). Gangliosides containing gangliotetraose are abundant in mammalian brains, where they can cover 10%–20% of the total ganglioside mixture. They are found in epithelial membranes and are key elements for bacterial toxicity and viral infection, for example, it is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. They can function as neurotrophic and neuroprotective compounds, and have been used therapeutically for diabetic and peripheral neuropathies. They bind amyloid-β proteins and are involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    Asialo-GM1-tetrasaccharide;b1-3Gal-N-acetyl galactosaminyl-b1-4 Gal-b1-4-Glc;Asialo GM1 oligosaccharide;Gal-b1,3-GalNAc-b1,4-Gal-b1, 4-Glc
    
    CAS Number
    
    75645-24-8
    
    Molecular Formula
    
    C26H45NO21
    
    Molecular Weight
    
    707.64 g/mol
    
    MDL Number
    
    MFCD05663667
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
    Chiricozzi et al (2020) GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration, International Journal of Molecular Sciences, 21(3), 868.