F1

F1

Catalog Number:
P004516690LIF
Mfr. No.:
PEPTIDE-PP-220
Price:
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  • Size:
    1mg
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      • Overview

        • Blocks the association of IKKbeta and NEMO.
          F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as
          IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice.

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      • Properties
        • Categories
          Cell Penetrating Peptides
          Alternative Name
          F1 peptide, TAT-IKIP (46-60)
          Molecular Formula
          C145H246N48O31S
          Molecular Weight
          3189.91
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble in water
          Other Properties
          Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Leu-Ser-Leu-Ala-Met-Thr-Leu-Gly-Leu-Ala-Trp-Leu-Val-Phe-OH,YGRKKRRQRRRLLSLAMTLGLAWLVF
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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