Name: Myr-tat-CBD3
Price: 397.00 USD

- Overview
  - Blocks the ? CaV2.2 ?CRMP2 interaction.
    Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PN-160), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2 ?CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision induced thermal and mechanical hypersensitivity without producing rewarding behaviour.
    
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    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Molecular Formula
    
    C148H269N59O33
    
    Molecular Weight
    
    3459.2
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in DMSO
    
    Other Properties
    
    Sequence: Myr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH,Myr-YGRKKRRQRRRARSRLAELRGVPRGL
    Modification: Myristoyl at N terminal
    
    Storage
    
    Store desiccated, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Myr-tat-CBD3

Myr-tat-CBD3

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