Name: iSP2
Price: Inquiry

- Overview
  - STAP-2 – CD3zeta ITAM interaction blocker.
    iSP2 is a peptide derived from residues of signal-transducing adaptor protein-2 (STAP-2) identified as interacting with cluster of differentiation 3 zeta (CD3zeta) immunoreceptor tyrosine based activation motifs (ITAMs) conjugated to octa-arginine to enhance cell penetrating ability. STAP-2 is an adaptor protein that positively regulates T-cell receptor (TCR) signaling by associating with TCR proximal CD3zeta ITAMs and lymphocyte-specific protein tyrosine kinase. iSP2 directly interacts with the ITAM sequence and competitively inhibits STAP-2 – CD3zeta ITAMs interaction and decreases TCR activation in human and murine T cells. In murine models of experimental autoimmune encephalomyelitis, iSP2 significantly suppresses disease development, to a similar extent to that seen in STAP-2 knockout mice.
    
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- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    STAP-2-derived synthetic peptide, R8-SP2-332/336, R8 STAP-2 C332/336
    
    Molecular Formula
    
    C85H152N40O16
    
    Molecular Weight
    
    1989.23
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Trp-Pro-Val-Ile-Leu-OH,RRRRRRRRGGWPVIL
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

iSP2

iSP2

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