Name: MMI 0100
Price: 275.00 USD

- Overview
  - MAPK-activated protein kinase II inhibitor.
    MMI 0100 is a cell-permeable peptide inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2). YARAAARQARA, also known as PDT-4, is the fragment that confers cell permeability and it also provides more selectivity to inhibit MK2. MK2 is activated by the MAP kinases p38 and p38, which in turn are activated by environmental stresses including heat shock, hypoosmolarity, hypoxia and inflammatory cytokines, and inhibition of MK2 may be beneficial in multiple human diseases including neuroinflammation, cancer, neural ischemia, rheumatoid arthritis, and inflammatory bowel disease. Neuroinflammation is considered a causative agent in Alzheimer’s disease (AD) and accordingly, in mouse models of AD, MMI 0100 ameliorates the memory deficit induced by A1 42 or lipopolysaccharide in novel object and location tasks. Similarly, in models of acute colitis induced by dextran sodium sulfate (DSS), MMI 0100 attenuates DSS-induced body weight loss, colon length shortening, and colonic pathological injury.
    
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- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    YARA, MMI-0100
    
    Molecular Formula
    
    C98H171N37O26
    
    Molecular Weight
    
    2283.64
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Other Properties
    
    Sequence: H-Tyr-Ala-Arg-Ala-Ala-Ala-Arg-Gln-Ala-Arg-Ala-Lys-Ala-Leu-Ala-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH,YARAAARQARAKALARQLGVAA
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

MMI 0100

MMI 0100

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