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Overview
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EtDO-P4 is a glucosylceramide synthase inhibitor which reduces the cellular levels of glucosylceramide (Glc-Cer) and the common biosynthetic precursor of most glycosphingolipids (GSLs). EtDO-P4 binds to the Glc-Cer synthase in a competitive manner and prevents the transfer of the first glucosyl residue, thus preventing further biosynthetic diversification into more elaborate glycosphingolipds. EtDO-P4 is a ceramide-like compound that was initially developed as a potential therapeutic for the treatment of diseases associated with altered glycosphingolipid levels. EtDO-P4 has also been used to indirectly increase sialylation levels in erythropoietin production. EtDO-P4 has been suggested, as part of compositions, for treatment of cardiac hypertrophy (Kwak, 2017).
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