DTPA anhydride - Amerigo Scientific

- Overview
  - DTPA anhydride is utilized to add chelate functions to molecules or surfaces with amine groups. After adding chelate functions, metal ions such as radioisotopes can be introduced to the molecule. According to Dr. Hnatowich, IgG may be labeled with radioactive indium using DTPA-anhydride. DTPA is first linked to IgG through a covalent bond, then In(III) is tightly chelated to DTPA. Such radioactive antibodies are known to bind with antigen in vitro and in vivo.
    
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- Properties
  - Categories
    
    Chelate Labeling
    
    CAS Number
    
    23911-26-4
    
    Molecular Formula
    
    C14H19N3O8
    
    Molecular Weight
    
    357.32
    
    Appearance
    
    Slightly yellow or yellowish-brown powder
    
    Purity
    
    ≥99.0% (Titration)
    
    Storage
    
    ambient temperature
    
    Shipping
    
    ambient temperature
    
    * For research use only
- Reference
  - 1) W. C. Eckelman, S. M. Karesh and R. C. Reba, New Compounds: Fatty Acid and Long Chain Hydrocarbon Derivatives Containing a Strong Chelating Agent, J. Pharm. Sci., 1975, 64, 704.
    
    2) B. A. Khaw, J. T. Fallon, H. W. Strauss and E. Haber, Myocardial Infarct Imaging of Antibodies to Canine Cardiac Myosin with Indium-111-Diethylenetriamine pentaacetic acid, Science, 1980, 209, 295.
    
    3) D. J. Hnatowich, W. W. Layne and R. L. Childs, The Preparation and Labeling of DTPA-Coupled Albumin, J. Appl. Radiat. Isot., 1982, 33, 327.
    
    4) D. J. Hnatowich, W. W. Layne, R. L. Childs, D. Lanteigne, M. A. Davis, T. W. Griffin and P. W. Doherty, Radioactive Labeling of Antibody: A Simple and Efficient Method, Science, 1983, 220, 613.
    
    5) C. F. Meares and D. A. Goodwin, Linking Radiometals to Proteins with Bifunctional Chelating Agents, J. Protein Chem. , 1984, 3, 215.
    
    6) A. Canfi, M. P. Bailey and B. F. Rocks, Fluorescent Terbium Chelates Derived from Diethylenetriaminepentaacetic Acid and Heterocyclic Compounds, Analyst, 1989, 114, 1405.
    
    7) C. H. Paik, K. Yokoyama, J. C. Reynolds, S. M. Quadri, C. Y. Min, S. Y. Shin, P. J. Maloney, S. M. Larson and R. C. Reba, Reduction of Background Activities by Introduction of a Diester Linkage between Antibody and a Chelatein Radioimmunodetection of Tumor, J. Nuclear Medicine, 1989, 30, 1693.
    
    8) D. J. Hnatowich, Recent Developments in the Radiolabeling of Antibodies with iodine, Indium, and Technetium, Semi. Nucl. Medicine, 1990, 20, 80.

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